Department of Medicine,Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok,
Downstaging hepatocellular carcinoma to the Milan Criteria yields similar post-transplant
outcomes to tumors within the Milan Criteria: A systematic review and meta-analysis study
Introduction: Hepatocellular carcinoma (HCC) is one of the most common indications for liver
transplantation (LT). According to the EASL-EORTC guideline, LT in HCC that exceeds the Milan
Criteria (MC) but was successfully downstaged (DS) to meet the MC are showed to have similar
outcomes to those within the MC, however this assertion is still lacking the support of high-level studies.
This systematic review and meta-analysis study was performed to compare the survival and recurrence
outcomes between the DS and those within the MC to provide further evidence in support of this aspect
of the current guideline.